2010 SEP 11 – ( NewsRx.com) — Fresh data on infertility are presented in the report ‘The effect of patient gynecologic history on clinician contraceptive Atlas® tag pendant.’ According to a study from the United States, “Contraceptive providers have an important influence on women’s selection of contraception (see also Infertility). Previous studies suggest that clinicians inappropriately limit use of intrauterine contraception (IUC).”
“This study investigated the influence of patients’ gynecologic histories on recommendations for IUC and other methods of contraception. Videos of standardized patients varying by history of pelvic inflammatory disease (PID) and parity were shown to clinicians at meetings of national medical societies. Participants indicated their contraceptive recommendations for the patient and whether they would have concerns were the patient to use IUC. Five Elsa Peretti® Infinity Cross pendant twenty-four providers viewed one video of a standardized patient and completed the survey. Gynecologic history was significantly associated with recommendations for the contraceptive ring, contraceptive patch, and copper IUC. Many clinicians indicated that they had concerns about the use of IUC with respect to risks such as PID, infertility and ectopic pregnancy. Concerns about infertility and pain with use of IUC were related to gynecologic history. Patient gynecologic characteristics affect recommendations for some reversible contraceptive methods,” wrote C. Dehlendorf and colleagues.
The researchers concluded: “Clinicians continue to have concerns about IUC use despite evidence supporting its safety.”
Dehlendorf and Elsa Peretti® Cross pendant published their study in Contraception (The effect of patient gynecologic history on clinician contraceptive counseling. Contraception, 2010;82(3):281-5).
For more information, contact C. Dehlendorf, UCSF, Dept. of Family and Community Medicine, San Francisco, CA 94110 USA.
NewsRx.com) — New research, ‘Bromopyrrole alkaloids as lead compounds against protozoan parasites,’ is the subject of a report (see also Malaria). “In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10) and dibromopalau’amine (11), and the non-oroidin bromopyrrolohomoarginin (12), manzacidin A (13), and agelongine (14), obtained from marine sponges belonging to Axinella and Agelas genera have been screened in vitro against four parasitic protozoa, i.e., two Trypanosoma species (T. brucei rhodesiense and T. cruzi), Leishmania donovani and Plasmodium falciparum (K1 strain, a chloroquine resistant strain), responsible of human diseases with high morbidity and, in the case of malaria, high mortality. Our results indicate longamide B (8) and Elsa Peretti® Bottle pendant (11) to be promising trypanocidal and antileishmanial agents, while dispacamide B (3) and spongiacidin B (6) emerge as antimalarial lead compounds,” scientists in Napoli, Italy report.
“In addition, evaluation of the activity of the test alkaloids (2-14) against three different enzymes (PfFabI, PfFabG, PfFabZ) involved in the de novo fatty acid biosynthesis pathway of P. falciparum (PfFAS-II) identified bromopyrrolohomoarginin (12) as a potent inhibitor of PfFabZ. The structural similarity within the series of tested molecules allowed us to draw some preliminary structure-activity relationships. Tests against the mammalian L6 cells revealed important clues on therapeutic index of the metabolites,” wrote F. Scala and colleagues, University of Napoli Federico II.
The researchers Charm bracelet: “This is the first detailed study on the antiprotozoal potential of marine bromopyrrole alkaloids.”
Scala and colleagues published their study in Marine Drugs (Bromopyrrole alkaloids as lead compounds against protozoan parasites. Marine Drugs, 2010;8(7):2162-74).
For additional information, contact F. Scala, Universita di Napoli Federico II, Dipartimento di Chimica delle Sostanze Naturali, Via D Montesano, 49, I-80131, Napoli, Italy.
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